How Long Does Alendronate Sodium Stay In Your System?

Does zoledronic acid weaken the immune system?

It still remains unclear what role zoledronic acid plays.

“We know it affects the immune system and inflammation, and both of those are important in fighting infection and cardiovascular disease,” Colon-Emeric says..

Why was Fosamax taken off the market?

Merck received a warning letter from the FDA in 1997 for unfair and dishonest marketing practices regarding Fosamax. The letter stated that Merck had been overstating the benefits of the medications while downplaying the risks.

Does Fosamax affect teeth?

Jan. 2, 2009 — After having teeth pulled, 4% of patients in a study who were taking Fosamax developed a dangerous condition called osteonecrosis of the jaw, USC researchers report.

How long should a person take alendronate?

Comment. These “glass half-full, half-empty” results suggest that women at low risk for fracture may feel comfortable taking a break after 5 years of alendronate treatment. Other women, particularly those with prior fractures or very low bone density, may choose to continue.

What are the worst side effects of Fosamax?

Stop using alendronate and call your doctor at once if you have:chest pain, new or worsening heartburn;difficulty or pain when swallowing;pain or burning under the ribs or in the back;severe heartburn, burning pain in your upper stomach, or coughing up blood;new or unusual pain in your thigh or hip;More items…•

Do Fosamax side effects go away?

Some side effects of alendronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Who should not take alendronate?

You should not take alendronate if you have problems with your esophagus, or low levels of calcium in your blood. Do not take alendronate if you cannot sit upright or stand for at least 30 minutes after taking the medicine. Alendronate can cause serious problems in the stomach or esophagus.

What are the long term side effects of alendronate?

Abdominal or stomach cramps.blistering, peeling, or loosening of the skin.bloating or swelling of the face, arms, hands, lower legs, or feet.bone, joint, or muscle pain, severe and occasionally incapacitating.chest pain.convulsions.diarrhea.difficulty with breathing.More items…•

How long does zoledronic acid stay in your system?

The excretion of zoledronic acid by the kidney does not depend on the dose or the infusion time (Chen et al 2002). The drug can be detected in urine in trace amounts up to 28 days after the infusion, although adequate amounts are present in urine only in the first 24 hours (Chen et al 2002).

Is hair loss a side effect of alendronate?

Less common side effects of alendronate include: Hair loss.

What is the most common side effect of zoledronic acid?

Vomiting. Constipation. Flu-like symptoms; mild fever sometimes accompanied by malaise, chills, fatigue and flushing.

How long does zoledronic acid side effects last?

Symptoms of this reaction may include flu-like symptoms, fever, headache, chills, and bone, joint or muscle pain. These symptoms may begin during the first 3 days after you receive a dose of zoledronic acid injection and may last 3 to 14 days.

What is the safest drug to take for osteoporosis?

Estrogen Promotes Bone Production Estrogen replacement therapy used to be the only FDA-approved treatment for the prevention of osteoporosis because of the hormone’s role in producing bone.

Do you gain weight with Fosamax?

Significantly increased weight gain of Fosamax-treated mice, particularly in the later weeks of treatment, suggest that long-term Fosamax use appears to impact metabolism, but it is unclear at this stage how these metabolic changes may lead to complications observed with long-term use of bisphosphonates.

Can you just stop taking alendronate?

It may affect the way this medicine works if you do not. Do not stop using this medicine suddenly without asking your doctor. Tell your doctor if you do weight-bearing exercises, smoke or drink excessively. Your doctor will need to take these into consideration in deciding your dose.